Plasma MMP-9 – a Marker of Carotid Plaque Instability
نویسندگان
چکیده
منابع مشابه
Videodensitometric analysis of advanced carotid plaque: correlation with MMP-9 and TIMP-1 expression
BACKGROUND Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of MMP (TIMP) promote derangement of the extracellular matrix, which is ultimately reflected in plaque images seen on ultrasound. Videodensitometry can identify structural disturbances in plaques. OBJECTIVES To establish the correlations between values determined using videodensitometry in B-mode ultrasound images of advanced ...
متن کاملMMP‐1 and MMP‐9 regulate epidermal growth factor‐dependent collagen loss in human carotid plaque smooth muscle cells
Mechanisms underlying the rupture of atherosclerotic plaque, a crucial factor in the development of myocardial infarction and stroke, are not well defined. Here, we examined the role of epidermal growth factor (EGF)-mediated matrix metalloproteinases (MMP) on the stability of interstitial collagens in vascular smooth muscle cells (VSMCs) isolated from carotid endarterectomy tissues of symptomat...
متن کاملOxidized LDL in carotid plaques and plasma associates with plaque instability.
OBJECTIVE Oxidation of LDL plays a significant pathogenic role in atherosclerosis. In this study, we attempted to clarify the correlation between the morphology of human atherosclerotic plaques and the oxidized LDL (OxLDL) levels in plasma and carotid plaques. METHODS AND RESULTS OxLDL levels (ng/microg apolipoprotein B) in plasma and carotid plaques from 44 patients undergoing carotid endart...
متن کاملPlasma RANTES: a molecular fingerprint of the unstable carotid plaque?
Rupture of atherosclerotic plaques in epicardial coronary or carotid arteries may lead to myocardial infarction or stroke—the leading causes of morbidity and mortality in Western countries. Thus, timely detection of these unstable plaques before they rupture is a great medical need. Non-invasive plaque visualization using duplex ultrasound, computed tomography (CT) or magnetic resonance imaging...
متن کاملMacrophages and mast cells are involved in carotid plaque instability.
The aim of this study was to evaluate the role of macrophages and mast cells and of microvascular density in atherosclerotic plaques collected from 63 consecutive symptomatic and asymptomatic patients undergoing carotid endarterectomy for carotid disease. Results have shown no statistically significant differences between the two groups as concerns: (i) the degree of stenosis; (ii) the extentio...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: European Journal of Vascular and Endovascular Surgery
سال: 2001
ISSN: 1078-5884
DOI: 10.1053/ejvs.2000.1278